UBXN1 antibody (AA 262-312)

Catalog No. ABIN7451534

The Rabbit Polyclonal anti-UBXN1 antibody has been validated for IP. It is suitable to detect UBXN1 in samples from Human.

Quick Overview for UBXN1 antibody (AA 262-312) (ABIN7451534)

Target: UBXN1 (UBX Domain Protein 1 (UBXN1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This UBXN1 antibody is un-conjugated

Application: Immunoprecipitation (IP)

Product Details anti-UBXN1 Antibody

Binding Specificity: AA 262-312

Purpose: Rabbit anti-UBXN1 Antibody, Affinity Purified

Predicted Reactivity: Mouse,Rat,Bovine

Purification: Affinity Purified

Immunogen: between AA 262 and 312

Isotype: IgG

Application Details

Application Notes:

IP: 2 - 10 μg/mg lysate

WB: Not recommended

Restrictions: For Research Use only

Handling

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Expiry Date: 12 months

Target Details for UBXN1

Target: UBXN1 (UBX Domain Protein 1 (UBXN1))

Alternative Name: UBXN1

Background: Background: UBX domain-containing protein 1 (UBXN1) is a ubiquitin-binding protein that interacts with the BRCA1-BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. The interaction between UBXN1 and autoubiquitinated BRCA1, leads to the inhibition the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. UBXN1 is also a component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol.3 kDa protein, UBXD10, 2B28, and SAKS1.

Gene ID: 51035

NCBI Accession: NP_056937

UniProt: Q04323